Athira, blessed with a strong team, committed blue-chip investors and phase 2 ready pipeline, is in-licensing a mid phase 3 asset to create a compelling late stage clinical development company.
Lasofoxifene, an oral small molecule combined with CDK4/6 inhibitor abemaciclib in an >50% enrolled, potentially registrational phase 3 trial, aims to provide a new, safe and efficacious standard of care to treat ESR1-mutant metastatic breast cancer in patients who have progressed on aromatase inhibitors and prior CDK4/6 inhibitors. Laxofoxifene is a potent Selective Estrogen Receptor Modulator (SERM) which, unlike SERDs, targets only breast cancer tissue rather than degrading estrogen in the entire body. A phase 2 trial combo, has shown strong efficacy and quality of life and health benefits.
In parallel, the company will continue to progress ATH-1105, a novel, orally available, next generation small molecule designed to positively modulate the neurotrophic HGF system for potential treatment of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease and Parkinson's disease. The company is planning to initiate a phase 2 clinical trial in ALS patients in early 2026.